*KLOTHO gene was discovered in 1997, in mice, to extend the lifespan when overexpressed, while it accelerates aging when its expression is disrupted.
The name of this longevity gene comes from the Greek goddess Klotho. In Greek mythology, it was Klotho who controlled the lives and destinies of everyone.
The Klotho gene codes for a transmembrane protein, the extracellular domain of which is shed and secreted.
The secreted Klotho protein inhibits the phosphorylation of the IGF1 receptor which leads to the repression of the insulin / IGF-1 pathway. Therefore, Klotho activity results in an activation of **FOXO. Activation of FOXO will induce anti-aging activity by stimulating detoxification and DNA-repair genes.
YOUTH EXPERT™ Ultimate Corrective Cream is a powerful and innovative anti-aging cream designed for intensive re-densification and re-contouring of face, neck and decollete – real results™. Cream is suitable for daily care for skin of all types with lack of cohesion and visible sagging. Not recommended before aged 40.
Main components – FLEX-UP Sculpting™ composition:
Stimulation of natural growth factors of skin: Placental Proteins
Repair of Extra-Cellular Matrix (ECM): Crocus Chrysanthus Extract
Dermal strength improvement: Xymeninic Acid (restructuring of tissue architecture)
Contouring and lifting: Lipodipeptide Tyrosyl-Arginyl + Crystal Tears™
Nutrition: Apitoxin/Bee Venom (rich in proteins, peptides, phospholipids, amino acids, minerals)
Microcirculation: Caffeine + Troxerutin (derivative of plant-derived Rutin)
Hydration: Polyglyceryl-3 PCA + Hyaluronic Acid 50kDa
Lipid-restore: Lauryl Olivate (Hydrolipidic Dermollient)
UV/Sun protection: UV filters (Sunglasses for the Skin™)
Anti-oxidant: Vitamin E
Free of parabens, colourants, EGF (epidermal growth factors), hormones and estrogens.
1. Technology FLEX-UP Sculpting™ is the most powerful anti-gravity system offered by DERMEDICS®. It is an outstanding combination of the most powerful age reversing components (which are partly known from ECM and GEN’X collections) blended with the newest cosmetic ingredients available nowadays on world’s beauty market. This intensive formula is created for re-densifying and re-contouring the skin, thus to reverse skin sagging caused by gravity through:
Stimulating keratinocytes to secrete growth factors that could enhance the synthesis of collagen and elastin in the dermis (this effect on fibroblasts was comparable to the one of the transforming growth factor (TGF-β), a natural growth factor involved in ECM synthesis)
- Stimulating the oxygen consumption of epithelial cells and the cell’s metabolic process
- Improving the biomechanical properties of the skin as well as its quality
- Restoring the ionic equilibrium, as well as tissular and cellular hydration
- Reactivating of two youth proteins: KLOTHO* and FOXO**
- Awaking youth genes of skin involved in cellular activity to stimulate: synthesis of cellular RNA, DNA repair, cellular detoxification, synthesis of fibrillin (a large glycoprotein (~350 kDa), rich in cysteine, which is a main component of microfibrils – its expression is reduced during aging).
2. Sunglasses for the Skin™ – innovative UV filters encapsulated into micro-pearls to provide protection for the skin and to prevent direct contact with the skin ensuring optimum comfort which allows for both day and night application. UV filters are inactive during night.
- Unisex: for women and men, for skin of all types
- Deterioration of the appearance of the contour of face and neck
- Lack of skin elasticity and firmness (sagging skin)
- Appreciable loss of skin’s compactness (poor dermal-epidermal junction (DEJ))
- Unhealthy skin tone, as a symptom of poor level of nutrition and oxygenation
- Daily skin care for skin of all types (night and/or day application)
Cream contains UV filters and that is why it is recommended to be used during a day (itself or prior makeup). However, it can be used also during a night (if desired), because during a night UV filters are inactive and they have no impact on skin.
- Intensive re-densifying and re-contouring
- Stimulation of skin’s natural growth factors
- Reversing aging process for mature skin
- Rejuvenation of skin texture
- All round treatments against gravity (prevention and reduction)
- Daily skin care (day and night application)
- Treatments targeted on visible effects – visible improvement of skin texture in regular application
- Visible re-contouring and re-shaping effects: face and neck contours appear to be redrawn
- Re-activation of the synthesis of collagen, elastin and hyaluronic acid
- Improved skin cohesion and resistance to gravity (anti-sagging efficacy)
- Intensive nutrition in proteins, peptides, phospholipids, amino acids and minerals
- Improved functionality of lipid barrier of the skin to prevent from irritations and inflammations
- Deep oxygenation and hydration (reduction of dull skin tone)
- Improved microcirculation and capillary resistance
- Photo-protection against UV and free radicals (FR)
Main target: face, neck, décolletage.
Optional: top parts of hands and other (if desired).
Water/Aqua, Butylene Glycol, Ethylhexyl Methoxycinnamate, Glyceryl Stearate, Polyquaternium-37, Polyimide-1, PEG-100 Stearate, Glycerin, Hydrogenated Palm Kernel Glycerides, Hydrogenated Palm Glycerides, Lauryl Olivate, Myristyl Myristate, Polyglyceryl-3 PCA, Troxerutin, Placental Protein, Acacia Senegal Gum, Xymenynic Acid, Caffeine, Hydrolyzed Hyaluronic Acid, Pistacia Lentiscus (Mastic) Gum, Acetyl Dipeptide-1 Cetyl Ester, Bee Venom, Crocus Chrysanthus Bulb Extract, Bis-PEG/PPG-20/5 PEG/PPG-20/5 Dimethicone, Methoxy PEG/PPG-25/4 Dimethicone, Cetearyl Alcohol, Caprylic/Capric Triglyceride, Glyceryl Polyacrylate, Sorbitan Laurate, Ethylhexylglycerin, Silica, PVP, PEG-8, Alcohol, Hydroxyethylcellulose, Cetrimonium Chloride, Chlorophenesin, Sodium Citrate, Tocopherol, Potassium Sorbate, PVM/MA Copolymer, Ascorbyl Palmitate, BHT, Ascorbic Acid, Citric Acid, Parfum, Phenoxyethanol, Pentaerythrityl Tetra-di-tbutyl Hydroxyhydrocinnamate, Disodium EDTA.
For external use only. Keep out of the reach of children.
Contraindications: hypersensitivity to any component of the formulation (especially on bee venom).
Skin condition improvement visible after single application/treatment.
Regular application provides spectacular skin improvement.
This product is dedicated for professional use in beauty salon, as well as for home care (to extend the effectiveness of professional beauty procedures at home).
Professional: airless 100ml and 200ml (possible in the future)
Home care: airless 50ml